Thursday, 18 December 2014

Pharmaceutical Semisolid

INTRODUCTION:
Semisolid dosage forms are dermatological products of semisolid consistency and applied to skin for therapeutic or protective action or cosmetic function.

Semisolid dosage forms usually are intended for localized drug delivery. In the past few years, however, these forms also have been explored for the systemic delivery of various drugs. Semisolids constitute a significant proportion of pharmaceutical dosage forms. They can be applied topically to the skin, cornea, rectal tissue, nasal mucosa, vagina, buccal tissue, urethral membrane, and external ear lining.


TYPES OF SEMISOLID DOSAGE FORMS

1. Creams,
2. Ointments
3. Pastes
4. Gels etc.


Cream preparation

Creams are viscous semisolid emulsion system with opaque appearance as contrasted with translucent ointments. Consistency and rheological character depends on weather the cream is w/o or o/w.
  • Properly designed O/W creams are elegant drug delivery system, pleasing in both appearance and feel post application.
  • O/W creams are non greasy and are rinsable.

They are good for most topical purpose and are considered particularly suited for application to oozing wounds.

Process Flow Chart:



(Fig: Cream manufacturing)


Ointment preparation
Ointments are soft hydrocarbon based semisolid preparation, composed of fluid hydrocarbon meshed in a matrix of higher melting solid hydrocarbon petrolatum being a tasteless, odorless, unctuous material with a melting range. Since they are greasy nature so they stain cloths. Principle ingredients forming the system hydrocarbon and silicon oil are generally poor solvent for most drugs, seemingly setting a low limit on the drug delivery capabilities of the system.  

ENVIRONMENT
Temperature: 20-300 C
Humidity: 30-60 %

DOCUMENTS:
1. Standard Operating Procedure (SOP)
2. Batch Manufacturing Record (BMR)
3. Batch Packaging Record (BPR)
4. In House specification


Automatic Ointment/Cream Manufacturing Plant



  
Process Flow Chart:




(Fig: Ointment manufacturing)




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