Manufacturing Oral Liquid

 The oral use of liquid pharmaceuticals has generally been justified on the basis of ease of administration to those who have difficulty in swallowing solid dosage forms. A drug administed in solution is immediately available for absorption and in most case, is more rapidly and efficiently absorbed than the same amount of drug administered in a tablet or capsules.

Pharmaceutical dosage form has 3 type of oral liquid

1. Syrup

2. Suspension

3. Emulsion etc.

Syrup:

Syrups are oral preparations in which drugs are homogeneously distributed in a solution.

Suspension:

Suspensions are two phase heterogeneous systems in which solid particles are dispersed of suspended in liquid with the help of suspending agents.

Emulsion:

Emulsions are two phase systems in which two immiscible liquids are homogeneously distributed in a liquid with the help of emulsifying agent

Process Flow Chart:

(Oral liquid manufacturing)

  

WATER SUPPLY:

Demineralized water is supplied from water treatment plant. This water is then heated with steam at temperature of 180⁰ C. Then this hot water is used in the preparation of sucrose syrup which aids the solubility of ingredients and prevents microorganisms

Equipment used in oral liquid unit:

1. Syrup Vat

Anounts: 03

            Made in India

2. Pump

3. Homoginetor

4. Filter

DOCUMENTS:

1. Standard Operating Procedure (SOP)

2. Batch Manufacturing Record (BMR)

3. Batch Packaging Record (BPR)

4. Material Requisition Sheet (MRS)

4. In House specification